Biomolecular Object Network Databank
The databank integrates a number of existing databases to provide a comprehensive overview of the information currently available for a given molecule.
On December 14, 2005, Unleashed Informatics Limited acquired the commercial rights to The Blueprint Initiative intellectual property.
BOND facilitates cross-database queries and is an open access resource which integrates interaction and sequence data.
The results of a search provide small molecule, protein, and domain information for each interaction identified in the database.
Hogue, C et al. estimated that 45% of predictions that were not observed in the PDB data do in fact represent true positives.
BIND was originally designed to be a constantly growing depository for information regarding biomolecular interactions, molecular complexes and pathways.
As proteomics is a rapidly advancing field, there is a need to have information from scientific journals readily available to researchers.
BIND facilitates the understanding of molecular interactions and pathways involved in cellular processes and will eventually give scientists a better understanding of developmental processes and disease pathogenesis The major goals of the BIND project are: to create a public proteomics resource that is available to all; to create a platform to enable datamining from other sources (PreBIND); to create a platform capable of presenting visualizations of complex molecular interactions.
The HTP curators are responsible for the collection of storage of experimental data and they also create scripts to update BIND based on new publications.
LTP records are curated by individuals with either an MSc or PhD and laboratory experience in interaction research.
[7] In 2006, BIND was incorporated into the Biomolecular Object Network Database (BOND) where it continues to be updated and improved.
BIND was the first database of its kind to contain info on biomolecular interactions, reactions and pathways in one schema.
[7] PreBIND an associated system for data mining to locate biomolecular interaction information in the scientific literature.
The authors of this program have created an extension to traditional IUPAC nomenclature to help describe post-translational modifications that occur to amino acids.
The OntoGlyphs were developed based on Gene Ontology (GO) and provide a link back to the original GO information.
There are 34 functional OntoGlyphs which contain information about the role of the molecule (e.g. cell physiology, ion transport, signaling).
The protein is diagrammed as a straight horizontal line and glyphs are inserted to represent conserved domains.
Since its integration with the other components of BOND, sequences have been added to interactions, molecular complexes and pathways in the results.
Subscribers to the commercial versions of BOND fall into six general categories; agriculture and food, biotechnology, pharmaceuticals, informatics, materials and other.
Other countries with access to the commercial versions of BOND include Canada, the United Kingdom, Japan, China, Korea, Germany, France, India and Australia.
