1k67B:81-155 2bdoA:81-155 1k69B:81-155 3bdoA:81-155 1bdo :81-155 1a6x :81-155 1y8pB:186-260 1y8nB:186-260 1fyc :186-260 1y8oB:186-260 1ghk :3-76 1ghj :3-76 1gjxA:4-76 1qjoA:207-278 1iyu :3-73 1iyv :3-73 1lac :3-76 1lab :3-76 Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid.
Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme.
[1] Lipoamide acyltransferases have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group.
[2] The lipoic acid cofactor is found in a variety of proteins.