[1][2] It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns and profiles in them.

These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation.

PROSITE was created in 1988 by Amos Bairoch, who directed the group for more than 20 years.

[3] It provides additional information about functionally or structurally critical amino acids.

As of 26 February 2022[update], release 2022_01 has 1,902 documentation entries, 1,311 patterns, 1,336 profiles, and 1,352 ProRules.