[citation needed] In 1523 Pope Clement VII caused the reinstatement of the Petrucci family, and along with them Biringuccio was able to return from exile.

The family made an attempt (aided by Biringuccio) to regain Siena by force, but it failed.

[citation needed] In 1530, Siena entered a more peaceful phase, and Biringuccio returned.

[citation needed] In 1536, he was offered a job in Rome by the Church, and in 1538 he became head of the papal foundry, and director of munitions.

It also gives details of mining practice, the extraction and refining of numerous metals, alloys such as brass, and compounds used in foundries and explosives.

Biringuccio was a member of the secretive guild Fraternità di Santa Barbara.

It is divided into ten books dealing with minerals, semi-minerals, assaying, smelting, the separation of gold from silver, alloys, the art of casting metals (especially bells and cannons), and alchemy.