It is the diester derived from methacrylic acid and the bisphenol A diglycidyl ether.

Bearing two polymerizable groups, it is prone to form a crosslinked polymer that is used in dental restorations.

[3] For dental work, highly viscous bis-GMA is mixed with aluminosilicate particles, crushed quartz and other related acrylates; changes to component ratios lead to different physical properties in the end product.

[5] Concerns have been raised about the potential for bis-GMA to break down into or be contaminated with the related compound bisphenol A.

[2][7] Salivary esterases can slowly degrade bis-GMA-based sealants, forming Bis-HPPP.