Bishop Rosecrans High School is a private, Catholic high school, operated by the Roman Catholic Diocese of Columbus, located in Zanesville, in the U.S. state of Ohio.

In 1893 the Franciscan Sisters of Christian Charity (Manitowoc, Wisconsin) arrived at St. Nicholas and by 1921 they had also established a complete secondary program.

At one time, the high school's faculty was simultaneously served by priests of the Columbus Diocese, Dominican priests and brothers, the Manitowoc Franciscans, and the Dominican Sisters of St. Mary of the Springs.

The Bishop Rosecrans Foundation was formed in 1986 to further the mission of Catholic secondary education in the region.

For the current academic year the school has 146 students[1] in grades 9-12 and well over 3,300 alumni.