Notre Dame High School is a private, Roman Catholic high school in Portsmouth, Ohio, United States.

It is a part of the Roman Catholic Diocese of Columbus.

[4] The school's athletic affiliation is with the Ohio High School Athletic Association (OHSAA) and the Southern Ohio Conference (SOC), which has seventeen member schools and is divided into two divisions (SOC I & SOC II) based on the schools' enrollment.

[5] Notre Dame is currently in SOC I. Notre Dame participates in baseball, boys' and girls' basketball, boys' and girls' cross country, football, boys' golf, fast-pitch softball, boys' and girls' swimming, boys' and girls' tennis, boys' and girls' track & field, and girls' volleyball.

See also Ohio High School Athletic Conferences and the Southern Ohio Conference.