Bita Moghaddam

[4] In 1986, Moghaddam published a first author paper in the Annals of the New York Academy of Sciences describing her improvements of the in vivo voltammetry method for applications in neuroscience.

[5] Moghaddam then published another first author paper highlighting her findings, using potassium-selective microelectrodes, that extracellular potassium concentrations vary across brain regions.

[8] At Yale, Moghaddam worked under the mentorship of Dr. Benjamin Bunney in the Department of Psychiatry exploring the modulatory effects of dopaminergic signalling in the striatum.

She first discovered that the cocaine administration in rodents induced a higher magnitude increase in extracellular dopamine in the Nucleus Accumbens compared to the Medial Prefrontal Cortex.

[11] Just before she began her faculty position at Yale, Moghaddam published another first author paper in the Journal of Neurochemistry reporting that administration of different antipsychotic drugs to rats has distinct effects on the release of dopamine in the Prefrontal Cortex, Nucleus Accumbens and the Striatum.

[8] She set up her lab to explore the neurobiology of midbrain dopamine neurons and prefrontal cortical subregions, key brain systems implicated in schizophrenia.

[13] In a study published in Psychiatry in 1991, the Moghaddam lab reported that Ventral Tegmental Area dopamine neurons are activated both before stimulus onset, signifying an internal state of anticipation, in addition to firing in response to rewarding post-stimulus outcomes.

[1] At Pitt, Moghaddam took on more teaching roles than she had previously at Yale, and she became a critical mentor to many young undergraduate students hoping to pursue opportunities in neuroscience.

[1] At Pitt, Moghaddam made many contributions to the field of neuroscience by continuing to probe how modulation of glutamate signalling affects behavior and neural circuit function in models for anxiety and schizophrenia.