The video also contains cameos from Diplo, Rita Ora, Chris Rock, Jon Kortajarena, Miley Cyrus, Alexander Wang, Beyoncé, Katy Perry, Kanye West, and Madonna's two sons, Rocco and David.

Additionally, comparisons ensued with then recently released music video for singer-songwriter Taylor Swift's single "Bad Blood", which had featured similar guest stars.

[33] Since Madonna had to rush-release the first six songs from Rebel Heart due to the hack and leaks, Diplo clarified that the released version on the album was not his final mixing of the track; he later posted his intended cut on his SoundCloud account.

[17] Fedde Le Grand's remix of the song did not use any of the effects present in the album version, and was created as an electro house track with metallic sounds.

Sasha Geffen from the Chicago Reader gave a positive review of the track, complimenting it for bringing the underground PC Music to the mainstream, adding that "between Diplo's blocky breakdowns and Sophie's slippery arpeggios, [the song i]s a provocative piece of work ...

"[29] Another positive review came from Neil McCormick of The Daily Telegraph, who elaborated: "[T]he track in question fizzes with bright energy, a handclapping rave anthem powered by a fantastically wonky synth line that sounds like a vintage arcade game played on an electronic kazoo, and topped off with a snappy Nicki Minaj rap.

[23] In contrast, Andrew Unterberger of the same publication enjoyed the track, claiming that "it might not be your favorite Madonna, but it's unquestionably her, and it's far more compelling than the anonymous EDM enthusiast she played on MDNA (2012)".

In lieu of one, producer Diplo comes up with a kind of hybrid of EDM and happy hardcore and throws Nicki Minaj at her most hyperactive into the mix; the result genuinely sets your teeth on edge.

"[41] Criticizing Rebel Heart for being "overworked", Sal Cinquemani of Slant Magazine found that "the duality of its title [is] muddled by the inclusion of garish party jams like the infuriatingly catchy but lyrically cringe-inducing 'Bitch I'm Madonna'".

[42] John Murphy of musicOMH remarked that the song "never quite lives up to its fantastic title, and just sounds a bit of a mess, trying to cram in Diplo-produced dance-hall rhythms, a dubstep breakdown and the seemingly now obligatory Nicki Minaj guest rap".

[43] Evan Sawdey of PopMatters opined that the song—and another Rebel Heart track, "Illuminati"—"absolutely reek of desperation, wanting so badly to shock and offend listeners that they fail to resolve as satisfying songs first and foremost".

[47] Similarly, while ranking the singer's singles in honor of her 60th birthday, Jude Rogers from The Guardian placed the track at number 67, calling it "energetic, but exhausting".

Sales for that week increased to 13,000 copies, enabling the song to reach a peak of number 5 on the chart, becoming Madonna's second top-ten single there following "Living for Love".

[57] In France, the song debuted at number 90 on the French Singles Chart the week of December 27, 2014, following the advanced release of the album's six tracks for pre-order on iTunes.

[60] A number of people were tagged in the Instagram post, including singers Beyoncé, Katy Perry, Miley Cyrus, and Rita Ora, as well as Minaj and Diplo.

[61] Comparisons ensued with the recently released music video for singer-songwriter Taylor Swift's single "Bad Blood" which had featured similar guest stars.

[63][64] Filming took place on the top floors of the Standard Hotel in New York City, and was directed by Jonas Åkerlund, who explained how he landed the project as follows: 'Madonna called me about 'Ghosttown'.

[65] A number of designers contributed clothing for the singer to wear, including Moschino, Discount Universe, SSUR, Chanel, Majesty Black and shoes by Giuseppe Zanotti.

[66] According to Amber Kallor from Style.com, various contemporary fashion trends appeared in the video, including candy-colored hairs, black lips, white bows and glitter eye makeup.

[68][69] Joe Lynch from Billboard compared the poster to those uploaded during the release of "Bad Blood" but nevertheless believed, "it's likely that Madge had this project in the works before becoming aware of Taylor's plans".

[72][73] The full list of guest appearances in the video included Beyoncé, Perry, Cyrus, Minaj, Ora, and Diplo along with rapper Kanye West, actor and comedian Chris Rock, designer Alexander Wang, model Jon Kortajarena and Madonna's sons Rocco and David.

As the chorus starts the scene cuts to four Japanese dancers (including AyaBambi) making choreographed moves in a bathtub and inside a bar as Madonna joins them.

The second verse starts with Madonna crawling along the hallway, getting entangled in balloons, meeting Diplo again and finally the camera pans away to reveal a number of sock puppets in neon glow swaying together to the song.

The song nears to an end and Madonna is shown surrounded by her dancers and some partygoers while she lies down; interspersed scenes show her twerking and dancing alone in a room wearing a cap with Hebrew word "שלום" ("Shalom") written on it.

Other scenes included Madonna chatting with Ora and Rock in-between takes, sitting in the hallways, plunging towards the neon sock puppets multiple times as well as singing the song with the little girls from the beginning of the video.

[80] Joe Lynch from the same magazine called the video an "embarrassment of star power", adding that it "has everything: Miley's middle fingers, Madonna kissing a shirtless hunk, topless women in a bathtub, break-dancing, sock puppets singing, Moschino fashion and much more".

[85][86] Christopher Rosa from VH1 criticized the fact that none of the female singers apart from Rita Ora were actually present on set during shooting of the video; their parts were filmed separately.

[93][94] Biance Gracie from Idolator gave a positive review to the performance, saying that "Instead of doing her usual bit of either singing 'Living for Love' or the current single 'Ghosttown', the entertainer decided to switch things up a bit—and we're so glad [she] did!

[100] The performance of the song at the March 19–20, 2016 shows in Sydney's Allphones Arena was recorded and released in Madonna's fifth live album, Rebel Heart Tour.

[103] It found the singer surrounded by dancers dressed like her throughout time, included a tribute to Michael Jackson and photos of "fairly random dead icons, crowing 'Bitch I’m Madonna' over and over".