There is a legend that the Black Tarantula was a European explorer, who traveled to Japan several centuries ago and was trained by the ninja clan called the Hand.

In reality, the Black Tarantula's immortality has a more earthly origin: the title is inherited from father to son, all posing as the same person (reminiscent of the comic strip character the Phantom).

The Black Tarantula hires Roughouse and Bloodscream to do his dirty work and drives back the Rose, establishing control over a large part of New York City.

[1] Spider-Man takes on the identity of Ricochet during the "Identity Crisis" storyline (faced with accusations of murder and assault, Peter temporarily abandoned the Spider-Man identity and donned four new costumes to continue his heroics while trying to clear his name), to infiltrate the Rose's organization and find out more about Black Tarantula, fighting Bloodscream and Roughouse with his former enemy Delilah (although she was, in fact, Black Tarantula's ex-wife who had fled the country with their son Fabian disliking the changes that Carlos underwent when he took on the mantle of Black Tarantula and did not want the same fate for her son).

Inside the mansion, Black Tarantula defeats Fortunato's guards including Spider-Man again, but loses his wife when she confronts him and points out that he is scaring his own son.

The leader of the yakuza gang flees from the attack; Daredevil chases him but fails to catch him because he has the flu, which is limiting his abilities.

This leader is a vengeful former recruit of Black Tarantula who, years before, Carlos had personally invited into his gang, naming him "Little Loco".

[3] Carlos LaMuerto's story is focused upon again in April 2008, in a one-shot issue entitled Daredevil: Blood of the Tarantula, where he turns in desperation to Matt Murdock to help his new 'mission'.

[8] Black Tarantula and White Tiger are then given the assignment to kill Foggy Nelson[9] by Lady Bullseye, who has been hired by the Owl.

Black Tarantula instead saves Foggy's life and then battles White Tiger, attempting to cure her of the Hand's influence.

[11] While New York was in crisis, Black Tarantula is ordered by White Tiger to execute looters, but he becomes confused and sees that something is wrong with Matt Murdock's motives.

However, White Tiger was still possessed by the Hand and stabbed Black Tarantula in his back with a blade, and tossed him over the edge of Shadowland to fall into a vehicle, leaving him for dead.

He has a powerful healing factor on a par with the likes of Wolverine or Deadpool that, combined with his superhuman durability, make him extremely difficult to seriously injure.