[2] The hospital is located in one of the fastest population growth areas in NSW, caring for patients from highly diverse cultural and social-economic status backgrounds.

Blacktown Hospital provides a wide range of health services including:[3] It operates a 24-hour emergency department and a full Intensive Care Unit and CCU.

[6] The original Blacktown District Hospital building was completed in January 1965 and "commenced rendering its service to the public on the 28th April, 1965".

[9] Nurses were given strict dress code instructions before the opening, including no eye make-up and wearing a distinct shade of lipstick.

Beds had "pretty bedspreads", vertical drapes and plenty of light, and were designed to feel like a bedroom at home.

The Lenterns were presented with a basket of flowers, a photograph album and a bottle of champagne to celebrate the first birth in the centre.

[16] In the first stage of expansion, Blacktown Hospital projects included facilities for sub-acute mental health, more parking, infrastructure and service enhancements and a new clinical services building for cancer, cardiac, respiratory and aged care, with an extensive art and culture program.

The building was officially opened by the then Premier of NSW Mike Baird and then Minister for Health Jillian Skinner on 17 May 2016.

Stage 2 of the project[18] is currently underway to deliver a new acute services building, car park expansion and further refurbishment.

The new acute services building will include facilities for emergency, operating theatres, intensive care, maternity, birthing, newborn health, and paediatrics.