The games' plots focus on Rosangela Blackwell, a spiritual medium, and her spirit guide Joey Mallone, who work to help ghosts transition to the afterlife.

The protagonist of the game is Rosangela Blackwell (Rosa), who is a young freelance writer living a solitary life in New York City.

Having been brought up in foster care after the early death of her parents and Institutionalisation of her aunt, Rosa is a reserved introvert who struggles with communication, though she is hardly interested in befriending others.

Joey is dry and sarcastic, frequently lamenting over the eternal and thankless nature of his work as a spirit guide, and is unable to be more than 30 feet away from his medium at all times.

Though Lauren largely resigned to her life as a medium and resents it for separating her from her brother, she is still very amiable and, unlike Rosa, is able to charm info out of people more readily.

She comically reveals in the final game that she had tried to prep Rosa for life as a medium by dressing up her prized teddy bear like Joey.

Nishanti, a resident of the same apartment complex as Rosa, possesses contrasting personality traits that make her an amiable and outgoing individual.

Unlike Rosa, Jocelyn resented her job as a medium, preferring to spend her nights dancing with her peers than with Madeline, her guide.

Shortly after the Great Depression hit, Jocelyn decided to sever her connection to Madeline, and in doing so, she would go mad looking for a new spirit guide, and began referring to herself as the Countess.

Madeline appears to be of royal lineage of some European monarchy from several centuries prior, though some of her dialogue suggests that the era she once lived in is much more recent.

Originally serving as the spirit guide of the Countess, Madeline was abandoned by her and stuck in Limbo before plotting to return to life so that she may eventually die properly.