The story follows vampire hunter Eric Brooks as he attempts to stave off an invasion on Paris while struggling with his origins among both the undead and the living.

The game follows Eric Brooks aka Blade, a dhampir who has spent his life as "the Daywalker", a hunter of vampires and other creatures of the night, while struggling with his dual-heritage to the warmth of human society and the bloodlust of the undead.

[1] Marvel's Blade is a narrative-driven, third-person action-adventure title, representing a departure from previous games developed by Arkane Studios which were usually played from a first-person perspective.

[2] Arkane Lyon, the French-based development division of Arkane Studios known for their work on the Dishonored series and Deathloop (2021), had begun preliminary work on their next project by January 2022, by which point Deathloop's campaign designer Dana Nightingale, had been tapped to serve as their new game's campaign director.

[1][10] An untitled licensed game from Bethesda Softworks was mentioned in the publisher's internal roadmap documents as slated for the 2024 fiscal year ending September 30, 2024.