[4] With the core gameplay following the same style of past Lego titles, the game features the ability to manipulate time and a four-player competitive Super Hero battle mode.

For example, Star-Lord is capable of flight, Black Panther can activate claw switches, and Spider-Man can swing on his webs, crawl on walls, and use his spider-sense to detect hidden objects.

[12] The ability to manipulate time is allowed to players directly from the new open world of Chronopolis, which is a myriad of 17 different Marvel locations (consisting of a variation of Ancient Egypt, an apocalyptic Asgard, Attilan, Hala, the Hydra Empire, K'un-L'un, Knowhere, Lemuria, Man-Thing's Swamp, Manhattan, an alternate version of Medieval England, a Marvel Noir version of New York City called Manhattan Noir, Nueva York, a variation of the Old West, Sakaar, Wakanda, and Xandar) linked through time and space and surrounding Kang the Conqueror's Citadel.

Meanwhile, at Avengers Mansion, Nick Fury presents the Avengers with several missions: Captain America, She-Hulk, and Thor fight the Presence in Siberia; Iron Man and Captain Marvel defeat Attuma at his underwater base; and Spider-Man, Ms. Marvel, and White Tiger battle escaped Raft prisoners on the Brooklyn Bridge, including most of the Sinister Six.

The Guardians of the Galaxy arrive just before Kang uses his devices to steal Manhattan with the heroes inside it and make it part of his battle arena called Chronopolis, consisting of various locales that he has stolen from across time and space with his citadel at the center.

Captain America leads a team through a portal to medieval England, where they help Sir Percy reclaim his castle from Enchantress and the Black Knight.

Another team led by She-Hulk follows Klaw and the Hydra Four through a portal to Wakanda, where Black Panther joins them to fight Man-Ape in the vibranium mines.

The heroes converge in a version of Manhattan ruled by Hydra, where they battle Klaw and vibranium robot soldiers created by Arnim Zola, and defeat Baron Zemo in a dogfight.

Proceeding to the Alchemax building in Marvel 2099's Nueva York, Spider-Gwen and Spider-Man 2099 help the group defeat the Green Goblin 2099 and "Carnom" (a fusion of Venom and Carnage) to obtain another fragment.

Moving on to Ancient Egypt, they enter a Sphinx and join Horus of the Heliopolitans in facing Loki and N'Kantu, the Living Mummy to obtain another fragment.

The heroes celebrate their victory, and Ravonna promises to return the components of Chronopolis to their original places in time and space once the remaining villains are dealt with.