The Blagoevgradska Bistritsa (Bulgarian: Благоевградска Бистрица) is a river in south-western Bulgaria, a left tributary of the Struma.

It is 41 km long and drains the southwestern parts of the Rila mountain range.

[1] Blagoevgradska Bistritsa takes its source about 300 m southeast of the summit Golyan Mechi Vrah (2,617 m) in southwestern Rila at an altitude of 2,546 m. It initially flows a mountain stream south to Macedonia refuge, where it turns west in a deep valley covered with old-growth coniferous forests where trees reach heights of almost 60 m and protected within Parangalitsa biosphere reserve.

[1] Its catchment area covers a territory of 234 km² and represents 1.35% of Struma's total drainage basin.

[1] Common fish species in the river include brown trout, Struma barbel and European chub.