Blanche was the eldest daughter of Marquess William VIII Palaiologos of Montferrat and Elisabetta Sforza,[2] daughter of Duke Francesco I Sforza of Milan and Bianca Maria Visconti, after whom Blanche was named.

She then acted as regent for her young son, Charles, who had succeeded his father in his regnal and titular titles.

[3] She remained the ruler of Savoy until her son, who was seven years old at the time, was accidentally killed in a fall at Moncalieri.

Her surviving child Yolande fell ill and died three years later, without having produced any children; therefore Blanche's line became extinct.

In her will dated 12 February 1519, she named her choice of burial place which was the chapel of the Church of the Blessed Virgin in Carignano.