First Nation peoples have used the river for centuries, and their petroglyphs and rock paintings can be found on some shoreline cliffs.

[5] The river along with many other rivers on the east side of Lake Winnipeg is part of a unique wilderness area untouched by major developments such as logging roads, mines, or dams.

From 1980 to 2015, Bloodvein was only accessible by the HMV Edgar Wood Ferry during warm months.

The ferry operated for 35 years until it was cancelled in 2015, due to decreased usage after the completion of a road allowing access to Bloodvein.

[7] Northern pike, walleye, channel catfish, whitefish, lake trout, sturgeon (catch and release only), chestnut lamprey[5]