The river then flows north to empty into the Gulf of Saint Lawrence at Margaree Harbour, Nova Scotia.

The Margaree has been well known for a century for its trout and Atlantic salmon sport fishery, that draws anglers from near and far.

[2] The gravel bars of the upper Northeast Margaree provide spawning grounds for Atlantic salmon; its steep valleys provide habitat for American marten and the rare Gaspé shrew.

Scottish Highlanders began to settle in the Margaree Valley at the beginning of the 19th century.

HMCS Margaree, a World War II Canadian naval destroyer, was named after this river.