Other than attacking the temple, Xion also stabs a woman named Nagi, imbuing her with his power as well as that of Gaia's, making her both his lifesaver and enemy.

A year later, the dragon is about to break free again, causing disturbances among the zoanthropes triggering earthquakes.

In Nagi's ending, in addition to sealing the dragon and saving Ryoho, she kills Xion and the Unborn.

Four are new additions: The other fourteen return from previous games: The Japanese voice cast includes Akimitsu Takase as Yugo, Ruri Asano as Alice, Akira Ishida as Bakuryu, Yuki Hamano as Uriko, Kenji Hamada as Shenlong, Ayaka Kodama as Jenny, Akio Ōtsuka as Gado, Tōru Ōkawa as Stun, Shōto Kashii as Busuzima, Mitsuaki Madono as Xion, Nao Takamori as Nagi, Masakazu Suzuki as Reiji, Naomi Kusumi as Ryoho, Ema Kogure as Mana, Naoki Bandō as Long, Atsuko Tanaka as Marvel/Shina, Takeshi Aono as Kohryu and Eriko Fujimaki as Uranus.

The English voice cast includes Rob Narita as Yugo, Rumiko Varnes as Alice, Raj Ramayya as Bakuryu, Lynn Harris as Uriko, David Schaufele as Shenlong, Alison Noonan as Jenny, Murray Johnson as Gado, Ward Sexton as Stun, Micheal Rhys as Busuzima, Walter Roberts as Xion, Erica Ash as Nagi, Eric Kelso as Reiji, Angus Waycott as Ryoho, Helen Morrison as Mana, Chris Wells as Long, Karen Lee as Shina, Greg Irwin as Kohryu and Donna Burke as Uranus.