Boekelo (Dutch pronunciation: [ˈbukəloː]) is a village in the municipality of Enschede in the eastern Netherlands, the population is estimated at approximately 2,500.

After the opening of the Twentekanaal (Twente canal) the factory of the Koninklijke Nederlandse Zoutindustrie (Royal Dutch Salt-industry) was moved to Hengelo; currently it is called Nouryon Industrial Chemicals.

The internationally known beer brewery Grolsch moved to Boekelo, abandoning its factories in Groenlo and Enschede.

When the verzuiling disappeared, the shops gradually lost their distinct Catholic or Protestant clientele.

In Twente's bocage lie historical estates, among others Hof te Boekelo (an original manor house from 1570), De Weele, Zonnebeek en 't Stroot.