The Regiment was raised in 1821 as the nation, then as part of both the Viceroy of Lima and the then United Provinces of the Rio del Plata, was fighting the Spanish American wars of independence as guerrilla units siding with the Buenos Aires and Lima independent governments then.
In 1821, the Colorados Regiment's first references were to a militia unit led by the Upper Peru guerrilla leader, Jose Miguel Lanza, and had among its rosters future national heroes of Bolivia like Jose Ballivian, Mariano Torrelio, and Manuel Deheza, who were fighting for Upper Peru's independence from Spain.
During the War of the Pacific, Bolivia alongside Peru, fought for their respective nations' mining interests against the Chilean forces.
Bolivia's contributions to the war included 2 cavalry squadrons, an artillery battery, and three infantry battalions, all equipped with fusils and rifles, among them being the Bolivian Colorados.
Every year (except in 2009) the Colorados come back to the place of their glorious exploits to commemorate the Bolivians' gallantry and courage seen in this battle.
As one of the Bolivian Army's missions is for internal security, it is no wonder that the Colorados were involved in anti-guerrilla operations, supported by the United States, against the guerrillas led by Che Guevara in 1967 in places like Nancahuazu, Ovelo, El Espino, and many others.
), the slogan made famous by Ernesto Che Guevara, became the new motto by President Evo Morales, in line with the socialist stance of his government and party.
Among the opposition, the change of motto to the socialist one used by him in 1967 during his guerrilla war in the country has been met with criticism, even among former armed forces chiefs.
During Hugo Chavez's visit to Cochabamba on April 22, 2010, the Colorados formed the guard of honor during the arrival ceremonies.
The arms is round with a picture of a kneeling soldier of the Colorados in full dress uniform in the middle, with a rainbow above him.