This genus lives in deep-sea environments and provides a habitat for a plethora of other benthic species, giving Bolosoma an incredibly important ecological role in the ecosystems it is a part of.

The Bolosoma are benthic organisms that live exclusively in the deep sea, preferring hard, rocky substrates such as old lava flows.

[6] The substrate Bolosoma can grow on varies, with this genus being found on polymetallic nodules and softer surrounding sediments in areas such as the Clarion-Clipperton fracture zone.

[6] Similar to many other taxa of deep-water suspension feeders, the diet and feeding habits of Bolosoma are relatively unknown due to lack of study.

By observing how healthy the populations of Hexactinellida sponges like Bolosoma are in commercially important environments such as the Emperor Seamount Chain, scientists can draw conclusions about how best to manage fishing practices in those areas.