Botanist was located at the intersection of Lovejoy and 13th Avenue in northwest Portland's Pearl District, in a space previously occupied by Pink Rose and below an Office Depot store.

[7] The bar also partnered with Meals on Wheels and the winery Stoller to assist hospitality and restaurant workers, as well as seniors.

[8][9] Botanist operated from a nearby rooftop patio previously occupied by On Deck Sports Bar.

[10][11][12] A Change.org petition organized by Botanist seeking to allow takeout cocktail service received more than 1,600 signatures.

[13] In November 2020, Botanist confirmed plans to start takeout cocktail service in violation of state law; owners called the act a "Civil Disobedience Protest".