[3] As part of the main cast, Affion Crockett, Ilana Glazer, Darrell Hammond, Gabourey Sidibe, and Neely provide the voices of various characters.

Daniel Weidenfeld, executive producer of the aforementioned series, holds the same position on Sclopio Peepio, as does Neely and Dave Newberg.

Neely wanted to produce a fast-paced sketch comedy series because he feels both those qualities apply nicely to animation.

[6] Borrowing the method used for writing China, IL, the show's writers work in a room where they propose roughly 50 ideas for sketches in a sitting.

[2] With Sclopio Peepio, Weidenfeld expressed wanting a return to the arrangement and style of The Professor Brothers and Baby Cakes, two web series by Neely.

[9] Devin D. O'Leary of the Weekly Alibi found the show unfunny as a whole, perhaps interesting only to enthusiasts of the network's increasingly strange programming.