[1] The founding member of TrxG proteins, trithorax (trx), was discovered ~1978 by Philip Ingham as part of his doctoral thesis while a graduate student in the laboratory of J.R.S.
Trithorax complex also interacts with CBP (CREB binding protein) which is an acetyltransferase to acetylate H3K27.
[4] Aside from gene regulation, evidence suggests TrxG proteins are also involved in other processes including apoptosis, cancer, and stress responses.
[8] This is accomplished by preserving the epigenetic marks, specifically H3K4me3, established by maternally-supplied factors.
[9] TrxG proteins are also implicated in X-chromosome inactivation, which occurs during early embryogenesis.