Brain Drain first appears in The Invaders #2 (Oct. 1975) and was created by writer Roy Thomas and artist Frank Robbins.

After being freed from Brain Drain's control, the aliens commit suicide by jumping into a vat of chemicals.

Joining the Master's team Omega Flight in a new robot body, Brain Drain and other villains battle the heroes on several occasions, before finally being defeated.

[4][5] Brain Drain returns as an antagonist in The Unbeatable Squirrel Girl, but is quickly defeated due to his outdated technology and design flaws.

Brain Drain appears in Marvel’s Squirrel Girl: The Unbeatable Radio Show, voiced by Peter Hermann.