Brazil competed in the 2021 Junior Pan American Games in Cali–Valle, Colombia from 25 November to 5 December 2021.

A flag bearers at the opening ceremony were skateboarder Pâmela Rosa and swimmer Breno Correia.

[1] At the closing ceremony flag bearer was table tennis player Giulia Takahashi, who won four medals.

[3] The following is the list of number of competitors (per gender) participating at the games per sport.

[4] Miguel Hidalgo started in athletics and triathlon.Amanda Kunkel, Yana Camargo, Otávio Gonzeli and Pedro Guilherme Rossi started in cycling road and cycling track.