[4] This species is endemic to the Neotropics and can be found in caves and rainforests in Mexico, Guatemala, Panama, Colombia, Ecuador, Venezuela, Costa Rica, Brazil, Trinidad and Tobago, Cuba, Hispaniola (Dominican Republic), Guyana, Suriname, and French Guiana.

[1][5] Habitat preferences include areas of high moisture and little light, such as caves, tree hollows, and cracks in rocks.

[5] As typical for all roaches, individuals undergo hemimetabolous metamorphosis, which means the change from juvenile to adult is gradual.

One hypothesis is that the absence of the jostling and mutual stimulation which are found often in colony life could slow the developmental process.

[8] In other instances, lower temperatures and reduced humidity can lead to delayed maturation and an increase in the number of molts.

[7] Carbohydrate intake has been found to be related to male sex pheromone expression, dominance status, and attractiveness more so than protein.

[7] This would suggest they are actively increasing their carbohydrate consumption to maximize their reproductive fitness and attractiveness to potential female mates.

[7] After mating, the female B. giganteus is pregnant for life and stores the fertilized eggs in her ootheca, where they are incubated for roughly 60 days.

[10] After eating their fill, the young nymphs burrow into soil or somewhere dark and remain there until they have molted numerous times and reached maturity.

In B. giganteus, such an invasion elicits a humoral response, where specific proteins are produced or activated by the existence of a pathogen.

[9] The fat body, which is usually associated with storing and releasing energy depending on demands, induces several novel proteins when confronted with fungal cell walls.

[2] The microbe's job is to take nitrogenous waste such as urea and ammonia and process it into amino acids that can be used by the cockroach.

[12] Attached to these spiracles are tubes called tracheae that branch throughout the body of the cockroach until they associate with each cell.

[12] Because B. giganteus is so large, it is assumed to have a higher metabolic rate versus other cockroaches, such as Periplaneta americana, but in comparison, it is quite sluggish.

[13] The presence of alanine, cysteine, glutamic acid, leucine, proline, tyrosine, and valine is shared among different species of cockroaches, such as Blattella germanica and P.