Bread loafing

Bread loafing is a common method of processing surgical specimens for histopathology.

[1] The cut sections are mounted by embedding in paraffin or frozen medium.

[2] It has a higher false negative error rate than the CCPDMA method of tissue processing.

Bread loafing false negative error rate can be reduced by "cutting through the block".

If the whole "ribbon" was mounted, it would take an inordinate number of glass slides, and not be feasible.

Pictogram of margin controlled histology or CCPDMA
Pictogram of standard bread loafing histology
False negative in standard bread loafing histology