Brigham Circle is located at the intersection of Tremont Street and Huntington Avenue in the Mission Hill neighborhood of Boston, Massachusetts.
The commercial center of Mission Hill, it forms the southern tip of the Longwood Medical Area.
Huntington Avenue has had through lanes since at least the early 20th century; a small rotary was present at the junction of Francis Street on the northwest side.
The light rail MBTA Green Line E branch runs through the center of the circle.
The private Mission Hill LINK circulator, run with partial MBTA subsidy, also serves Brigham Circle.