Brockmann body

In addition, the teleost fishes can regenerate their endocrine tissues after harvest, the property of which has challenging implication in human diabetes.

[6] Both islet groups contain insulin, glucagon, peptide YY and somatostatin, but these proteins are secreted only in the pyloric Brockmann bodies.

An advantage of using teleost fish over other animals, such as pigs, in the studies of diabetes mellitus is that its endocrine cells are separated from the pancreatic exocrine tissue and can be easily isolated and harvested.

[9] Moreover, the teleost fishes can regenerate their endocrine tissues after harvest, implying that the property could be beneficial in type I diabetes mellitus.

[4] The Brockmann body of the tilapia (Oreochromis nilotica) is investigated as a potential xenograft tissue for patients with type 1 diabetes.

[10] The transplantation of tilapia Brockmann bodies into a diabetic mice model has been shown to promote long-term normal blood glucose level.

Brockmann bodies isolated from an Atlantic wolffish. (A) Pancreatic tissues are scattered in the mesentery (black arrows). (B) The Brockmann body is indicated with an arrow.