Bromacil was first registered as a pesticide in the U.S. in 1961,[2] and by 1974 1,017,000 pounds (461,000 kg) was used annually in the US, largely by government and industry.

Dry formulations containing bromacil must bear the word "Caution" and liquid formulas must signal "Warning.

Bromacil is slightly toxic if individuals accidentally eat or touch residues and practically nontoxic if inhaled.

[7] Bromacil (40%) is combined with the active ingredient diuron in the herbicide Krovar, which is used by companies such as the Washington State Department of Transportation (WSDOT).

[4] Because bromacil is a possible human carcinogen and systemic toxicity may result from intermediate exposure (one week to several months), U.S. Environmental Protection Agency (EPA) assessed risk to workers using several major exposure scenarios.