4-Fluorobromobenzene is synthesized via bromination of fluorobenzene in the presence of a Lewis acid catalyst such as iron(III) bromide or aluminium tribromide.

[2] 4-Bromofluorobenzene is regarded by the Toxic Substances Control Act as a high production volume chemical, that is, a chemical that 1 million pounds (about 500 tonnes) per year is either produced in or imported to the United States.

As of 2002, companies producing or importing this compound reported 10 million (4,536,000 kilograms) used.

This is up from 500,000 pounds (226,800 kilograms) used in 1986, as reported in the Inventory Update Rule of the Toxic Substances Control Act.

[1] [3] 4-Bromofluorobenzene is a standard substrate for cross-coupling reactions[4][5] It forms a Grignard reagent used in the synthesis of 4-fluorophenyl containing compounds,[1][6] such as the pesticide Flusilazole.