She made seven complete voyages as a slave ship in the triangular trade in enslaved people.

1st voyage transporting enslaved people (1783–1784): Captain Robert Kendall sailed from Liverpool on 18 April 1783.

[2] On 1 January 1784 Brothers was reported on the coast of Africa, together with several other slave ships, including Bloom.

[2] 2nd voyage transporting enslaved people (1784–1785): Captain Kendall sailed from Liverpool on 28 July 1784.

[5] 4th voyage transporting enslaved people (1786–1788): Captain Richard Kendall sailed from Liverpool on 27 August 1786.

[8] 5th voyage transporting enslaved people (1788–1789): Captain Joseph Clark sailed from Liverpool on 14 September 1789.

[9] 6th voyage transporting enslaved people (1790–1792): Captain Alexander Finley sailed from Liverpool on 14 November 1790.

[d] 7th voyage transporting enslaved people (1792–1793): Captain Thomas Payne sailed from Liverpool on 6 May 1792.

[13] 8th voyage transporting enslaved people (1794–loss): In May 1795, Captain Archibald Galbraith sailed from Liverpool.

At end-April 1795 Lloyd's List reported that Brothers, Galbraith, master, had arrived at Grenada from Africa.

[15][f] Captain Ignacio Pica outfitted Nuestra Señora del Carmen with goods and provisions for a slaving expedition in 1794.

[g] While sailing in the Caribbean, she encountered the French privateer Brutus, Jean Gariscan, master, in April 1795.

[h] Captain Pica, realizing that Brutus was more powerful than Nuestra Señora del Carmen, immediately surrendered.

The three vessels (Brutus, Nuestra Señora del Carmen, and Brothers), sailed to Charleston.