He made his debut driving for HRT in 2010, raced for Renault from August 2011 as a replacement for Nick Heidfeld,[1] and drove for the Williams team in 2012.

[6] Senna started karting on the family farm at the age of five and was taught by his grandfather Milton and his uncle Ayrton, who was a Formula One driver for McLaren at the time.

[7] Senna stated his main influence was his grandfather and Ayrton, having learnt mechanics by fixing the engines of jet skis or go-karts that his uncle owned.

[9] Ayrton's death while driving a Williams at the 1994 San Marino Grand Prix, however, brought Bruno's own racing career to an abrupt halt.

Despite these setbacks including the death of his father in a motorbike accident in 1996, Bruno's mother and his uncle Ayrton's sister Viviane had reluctantly backed her son's interest in motor racing.

Senna drove the car at the 2004 Brazilian Grand Prix meeting in São Paulo, at Interlagos, where Ayrton had won in 1991 and 1993.

In 2004, Bruno competed in six races of the Formula BMW UK series for Carlin Motorsport, scoring six points.

In 2006 he stayed with the team and finished third in the series standings behind champion and teammate Mike Conway and Oliver Jarvis, taking five victories.

A poor qualifying session at the Nurburgring for the feature race meant Senna started 16th but was up to ninth after a cleverly timed first pit stop.

At Spa Senna showed raw pace through practice and set the third fastest time early on during Qualifying for the feature race.

However a stall on the grid meant he started 22nd and while fighting to make up ground he got a bit of oversteer and then the camber changed, ending his day in the tyre barrier.

Starting at the back of the grid for the sprint race, Senna finished eighth leaving Belgium pointless.

This was a positive season on the whole for Senna finishing in the top 10 in only his third full year of single seater racing, with one win and three podiums.

It also moved Senna to first position in the points table, although he was to eventually finish runner-up in the championship to Giorgio Pantano.

Bruno Senna sampled a contemporary Formula One car for the first time in November 2008 when he tested for Honda in Barcelona.

Despite Senna, over the course of the three-day test, coming to within 0.3 seconds of then Honda F1 racing driver Jenson Button, the later announcement that Honda would withdraw from Formula One with immediate effect amid the economic crisis appeared to have significantly lessened his opportunity of a 2009 race seat in Formula One, unless the squad were to find a buyer before the beginning of the season in March.

[19] Senna decided not to sign with Mercedes for the 2009 Deutsche Tourenwagen Masters season "to focus completely on his Formula One chances".

He also wished Bruno the very best in the future, saying he only had a position as Ross Brawn chose the more experienced person because of lack of testing time.

[24] It was unclear whether Senna still had the drive after the takeover of Campos by José Ramón Carabante, with new team principal Colin Kolles saying the new-look team would need to find extra funding, review the existing operation, and announce the driver line up in due course, with no mention of Senna.

[26] Senna returned to the driver's seat for the German Grand Prix with Yamamoto replacing Chandhok in the team's other car.

[1] He qualified seventh for his first race with the team, the Belgian Grand Prix, and finished 13th after colliding with Jaime Alguersuari at the first corner, for which Senna received a drive-through penalty.

In Singapore, the Renault cars struggled with grip on the slow street circuit, with Senna qualifying and finishing 15th, ahead of teammate Petrov.

Senna finished 16th in Japan, 13th in Korea, and 12th in the first Indian Grand Prix, after being forced to change tyres late in the race.

In Abu Dhabi, Senna again finished 16th after receiving a drive-through penalty for ignoring blue flags, and suffering a KERS failure.

Senna finished the season 16th in the Championship on 31 points and was dropped by Williams for 2013 in favour of Finnish rookie Valtteri Bottas on 28 November 2012.

At Le Mans, the Aston Martin Vantage GT2 #99 driven by Senna, Rob Bell and Frédéric Makowiecki started from pole position[42] in the GTE class but did not finish the race after serious crash with 5 hours to the end, when running 3rd.

On March 10, 2022, electric vertical take-off and landing (eVTOL) racing series Airspeeder confirmed Senna as a development pilot and global ambassador.

[48] On 7 March 2014, Senna was added to Sky Sports F1's line-up for seven races: Malaysia, China, Hungary, Singapore, Russia, USA and Brazil.

Senna also commentated during practice sessions alongside David Croft as well as providing race analysis with the presentation day throughout the seven Grand Prix weekends.

[49] On 8 March 2016, Senna was announced as part of Channel 4's Formula One coverage, appearing in special features throughout the season.