He also played in MLB for the Texas Rangers, Boston Red Sox, Miami Marlins, Baltimore Orioles, and Arizona Diamondbacks.

He was also named a Second Team All-American and won the Johnny Bench Award as the top collegiate catcher for the season.

[13][15] The Detroit Tigers selected Holaday in the sixth round of the 2010 Major League Baseball Draft.

He signed, and played for the Lakeland Tigers of the Class A-Advanced Florida State League that season.

[10] He played for the Erie SeaWolves of the Eastern League, the Tigers Class AA affiliate, during the 2011 season.

He started the season with the Toledo Mud Hens of the Class AAA International League, where he batted .248 with no home runs and ten RBIs.

[18] The Tigers promoted Holaday to the major leagues on June 6, 2012, as the team added him to their 40-man roster due to injuries to starting catcher Alex Avila.

He became the third position player selected in the 2010 draft to reach the majors, following Bryce Harper and Kole Calhoun.

Once again, Holaday entered spring training in 2016 competing for a backup role, this time with Jarrod Saltalamacchia.

Despite losing the job, Holaday attracted large amounts of trade interest due to hitting .438/.455/.969 in 16 games and his lack of minor league options remaining.

On March 29, 2016, the Tigers traded Holaday to the Texas Rangers in exchange for Bobby Wilson and Myles Jaye.

[28] On March 31, 2017, the Tigers signed Holaday to a minor league contract and assigned him to the Toledo Mud Hens.

[35] On January 13, 2020, Holaday signed a minor league deal with the Baltimore Orioles that included an invitation to spring training.

[42] Holaday's older brother, Bobby, also played for the baseball team at Warren Travis White High School.