[8] As a sophomore in 2018, he batted .408/.505/.628 with nine home runs and 83 RBIs and helped lead Oregon State to win the 2018 College World Series, their 3rd NCAA Division I Baseball National Championship.

[12] In late June, Rutschman was named the 2019 recipient of the Buster Posey Award, which is given to the nation's top collegiate catcher.

[17] He made his professional debut with the rookie–level Gulf Coast League Orioles, and, after five games, was promoted to the Low–A Aberdeen IronBirds.

[23] On August 9, 2021, Rutschman was promoted to Triple-A Norfolk Tides, after slashing a .271/.392/.508, with 18 home runs and 55 RBIs in 80 games with Bowie.

[24][25] Rutschman competed for a spot on the Orioles 2022 Opening Day roster, but he missed the start of the season due to a strained triceps muscle.

[29] He was the first major-leaguer to accomplish that feat (a triple for his first MLB hit) since Jason Perry did so in his first Major League at-bat for the Atlanta Braves in 2008.

On June 15, Rutschman hit his first major league home run off Toronto Blue Jays starter José Berríos.

[37] Rutschman was a finalist at catcher for the Gold Glove Award, losing to Jonah Heim of the Texas Rangers.

[40] On April 19, 2024, Rutschman hit his first career grand slam off of Kansas City Royals reliever Will Smith.

The first was a one-out solo homer off Yusei Kikuchi in the sixth inning, the second a two-out two-run shot off Zach Pop in the eighth.