Its location is also of importance in that this terminal normally is the first or last stop in the United States on the busy Toronto-New York City bus corridor in the United States (the exceptions being a re-routed Buffalo to Toronto runs serving Buffalo Niagara International Airport on the way to the Rainbow Bridge, where it crosses into Ontario).

Built in 1977, the architectural firm of CannonDesign created a terminal that is a "pleasant and even exciting space to experience, with views of travelers, buses and the city beyond afforded by comparatively large areas of glazing".

After the Main Street station had closed, it became a police station for the Buffalo Theater District, and is currently used partially as the Alleyway Theatre[2] Aside from the transportation center being the main office for the Niagara Frontier Transportation Authority and the Buffalo area base office for Greyhound Lines, Inc., there are a number of service based businesses for passengers and employees of the terminal.

In the past, Hardee's and Burger King had an outlet in the terminal that was later turned into a "Travelers Cafe", both operated by Greyhound Lines.

Additionally, a gift shop existed for a number of years, but has been vacated and renovated into a larger office area for the NFTA Transit Police sub-station.