[13] During Prohibition, the distillery was allowed to remain operational, in order to make whiskey for "medicinal purposes".

In 2016, Buffalo Trace Distillery announced plans to expand operations with a capital investment of $200 million.

[15] In March 2022, Buffalo Trace Distillery announced the creation of six-litre OFC Vintage Bourbon Whiskeys, distilled in 1982, and their accompanying NFTs.

The sale was part of the distillery's mission to raise US$2 million for charity by donating 2,022 bottles of whiskey to fundraising causes.

[16] Production capacity at Buffalo Trace is estimated at 2,650,000 US gallons (10,000,000 L) of whiskey per year.

[17] While Buffalo Trace Distillery is mainly known for its bourbon, it also produces other spirits such as rye whiskey and vodka.