The range is adjacent the Utah border and attached to the Clover Mountains of southeast Nevada.

The Bull Valley Mountains are on the water divide between the Escalante Valley north, the location of Enterprise in the southern Escalante Desert of the Great Basin, and the watershed of the Colorado to the south.

Utah Route 18 traverses the base of the southeast escarpment and upper Santa Clara River; Route 18 then goes due north through the east end of the Bull Valley Mountains to Enterprise.

The route also travels due south from the escarpment through Snow Canyon State Park, then to Saint George.

A separate route skirts the center of the escarpment's foothills, going from Veyo, then along the Santa Clara to Gunlock; the southwest third of the Bull Valley Mountains is drained southwest into the Beaver Dam Wash, west of the Beaver Dam Mountains.