The Society for Mathematical Biology (SMB) is an international association co-founded in 1972 in the United States by George Karreman, Herbert Daniel Landahl and (initially chaired) by Anthony Bartholomay for the furtherance of joint scientific activities between Mathematics and Biology research communities.

[8] Professor Rashevsky also founded in 1969 the non-profit organization "Mathematical Biology, Incorporated"—the precursor of SMB.

Another notable member of the University of Chicago school of mathematical biology was Anatol Rapoport whose major interests were in developing basic concepts in the related area of mathematical sociology, who cofounded the Society for General Systems Research and became a president of the latter society in 1965.

SMB secretary is Jon Forde (Hobart and William Smith Colleges), and treasurer is Stanca Ciupe (Virginia Tech).

The Bulletin was founded by Dr. Nicolas Rashevsky, who is generally recognized as the founder of the first organized group in mathematical biology in the world.