It can be used to treat bovine East Coast fever protozoa in vitro, along with the only other substance known – Peganum harmala.

[citation needed] It is the only really effective commercial therapeutic product against bovine theileriosis, where it has been used since the late 1980s.

[citation needed] Its patent expired in the mid-2000s, and was then produced in different countries such as India and Iran.

[citation needed] Using a single dose of 2.5 mg/kg, the recovery rate of curable cases is 90 to 98%.

[2] Buparvaquone resistance appears to be associated with parasite mutations in the Qo quinone-binding site of mitochondrial cytochrome b.