Burundi competed at the 2012 Summer Olympics in London, United Kingdom from 27 July to 12 August 2012.

Swimmer Elsie Uwamahoro was the only athlete in the team to participate in her second Olympics.

Marathon runner Diane Nukuri, the oldest athlete of the team, made an Olympic comeback in London after a twelve-year absence, and reprised her role as Burundi's flag bearer at the opening ceremony.

Burundi, however, failed to win a single Olympic medal in London.

Track runner Francine Niyonsaba qualified for the final rounds in the women's 800 metres, but narrowly missed out of the nation's first ever medal after 16 years, finishing abruptly in seventh place.