The delegation sent by the Sammarinese National Olympic Committee consisted of four athletes: sprinter Martina Pretelli, archer Emanuele Guidi, trap shooter Alessandra Perilli and short-distance swimmer Clelia Tini.

Three of the four Sammarinese athletes qualified for the Games by using wild cards for their respective events, bar Perilli who made the Olympics by meeting the required criteria for her sport.

Although Pretelli, Guidi and Tini were unable to advance beyond the heats of their contests, Perilli came joint second in the final of the women's trap shooting event.

[2] The Sammarinesi delegation consisted of four athletes, archer Emanuele Guidi, sprinter Martina Pretelli, trap shooter Alessandra Perilli and short-distance swimmer Clelia Tini.

They were accompanied by a press officer and five officials, including the San Marino State Secretary for Sport, Fabio Berardi, and the President of the Sammarinese National Olympic Committee, Angelo Vicini.

"[10] Martina Pretelli was the sole representative of San Marino in athletics and was making her début at the Olympics at the age of 23.

[14] Pretelli was drawn in the fourth heat of the women's 100 metres on 3 August, finishing third out of nine runners with a time of 12.41 seconds.

[14][17] She qualified for the women's trap contest by earning a quota spot through a victory in the 2011 ISSF World Cup in March that year.

[19] At the end of the final, Perilli was tied for second place with France's Delphine Réau and Zuzana Štefečeková of Slovakia with 93 points out of a possible 100.