US 10 was created by 1960 to follow Chestnut and Church streets into the community's central business district and through adjacent residential areas.

The Midland business loop dates back to 1961 and follows Eastman Avenue and two sets of one-way streets before completing its routing as a freeway.

They followed streets that were once part of US 10, but, after additional changes to US 10's routing in Michigan, they were renumbered as business loops of other highways in 1962 and 1986, respectively.

The business loop continues easterly out of downtown and angles northeasterly before crossing the Hersey River and the Pere Marquette State Trail again.

[4][5] According to the Michigan Department of Transportation (MDOT), the agency which maintains the roadway, between 1,949 and 5,499 vehicles per day used the business loop on average daily in 2013.

[9] The business loop was created after US 10 was moved to bypass downtown Reed City in the late 1950s.

[1][2] Until 1986, the western half of the loop along Chestnut Street ran concurrently with US 131 until that highway was moved to its current freeway routing.

US 127 follows McEwan Street southward over the South Branch of the Tobacco River and through a residential area on the north side of the city.

Several blocks further south, the highway enters the downtown district and turns onto Fifth Street, separating from Bus.

US 10 runs parallel to the Pere Marquette Rail-Trail on Saginaw Road in a rural section of Isabella County before terminating at an interchange that connects it to eastbound US 10 in Wise Township.

Through the city, the business loop has four lanes for traffic, but the rural segment in Isabella County has two.

[14][15] According to MDOT, the agency which maintains the roadway, between 4,035 and 6,540 vehicles per day used the business loop on average daily in 2013.

[9] In late 1961, the US 10 freeway east of the city to Midland was finished, but the route through downtown remained part of US 10.

US 10/M-20 passes Dow Diamond, home of the Great Lakes Loons, a Minor League Baseball team, and then the highway turns northeasterly.

As the freeway continues eastward, there is a partial interchange for Waldo Road, and then the highway crosses into the section of Midland that is located in Bay County.

[24][25] According to MDOT, the agency which maintains the roadway, between 7,317 and 23,733 vehicles per day used the business loop on average daily in 2013.

US 10 that runs concurrently with M-20 has been listed on the National Highway System,[26] a network of roads important to the country's economy, defense, and mobility.

[8] M-20 to the northwest of the city along with M-24 to the southeast (along what is today M-47) were renumbered to US 10 seven years later when the US Numbered Highway System was created.

[28] By the middle of the 1930s, US 10 was shifted to bypass downtown Midland, and the former route on the west side of town was numbered US 10A.

[32][33] Later, in 1962, US 10 was moved again to follow the recently completed I-75 freeway; the former route of US 10 was redesignated M-54, and its business loop was renumbered to match.

US 10 started northwest of downtown at the intersection of Telegraph Road and Dixie Highway in Waterford Township before crossing into the city of Pontiac.

US 10 merged onto a loop formed by Wide Track Drive around the downtown core southward to Saginaw Street.

The loop is shaped like an upside-down tear drop that is about four blocks wide at the northern end tapering to a single intersection at the south.

The business loop continued southward along Wide Track Drive to the intersection of Saginaw Street.

[39][40] Nine years later, US 10 was moved off Woodward Avenue between Pontiac and Detroit to follow the Lodge Freeway and Telegraph Road.

[44][45] In 1985, MDOT received permission from the American Association of State Highway and Transportation Officials to truncate US 10 to Bay City,[46] and, when the change was made the following year, US 24 replaced US 10 on Telegraph Road north of Square Lake Road, and Bus.