Butalamine

Butalamine is a vasodilator.

[1] The reaction of benzamidoxime (1) with chlorine and subsequent reaction with cyanamide (3) gives 5-amino-3-phenyl-1,2,4-oxadiazole (4).

[2][3][4] Base catalyzed alkylation with dibutylaminoethyl chloride (5) completes the synthesis of butalamine (6).

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Synthesis of butalamine