Cetiedil

Cetiedil is a vasodilator and an anti-sickling agent.

[1] The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid, CID:11064522 (1) gives cyclohexyl(thiophen-3-yl)acetic acid [16199-74-9] (2).

Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane [2205-31-4] (3) produces cetiedil (4).

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Thieme Original patents: [ 2 ] Prepn and activity: [ 3 ] Revised synthesis: [ 4 ] [ 5 ] Analogues: [ 6 ]