Byers Station Historic District is a national historic district located in Upper Uwchlan Township, Chester County, Pennsylvania, United States.

The district includes 26 contributing buildings in the crossroads community of Byers Station.

Notable buildings include a variety of residences, a factory, a Masonic lodge (1894), and the former Byers Hotel (c. 1874).

The community grew around the Byers railroad station, after its opening in 1871, and continued after plumbago (graphite) was discovered in the area in 1875.

[2] It was added to the National Register of Historic Places in 2002.