The college was a seat of English general education in the State of Travancore and is regarded as "the first locale to start English education"[citation needed] in Kerala and the first to have Englishmen as teachers in 1815 itself.
The first Malayalam Book printed in Kerala, Cherupaitangalku Upakarardham Englishil ninnu Paribhashapedutiya Kadhakal,(which consists of short stories for children translated from English) by Benjamin Baily was printed at CMS press in Kottayam in 1824.
C.M.S Press published complete Malayalam translation of the Bible in 1842 and a Malayalam- English Dictionary in 1846.
C.M.S Press undertook printing works in the languages of Malayalam, English, Tamil, Sanskrit, Latin and Syriac.
C.M.S Press was the first polyglot printing office as well as the first book publishing house in Kerala.