C15orf39

C15orf39 is a protein that in humans is encoded by the Chromosome 15 open reading frame 15 (C15orf39) gene.

Low expression levels of C15orf39 were found in the occipital lobe and PB-CD19+ B-cells.

[9] C15orf39 is composed of an above average level of proline (≈17%), and is deficient in isoleucine (≈1%) and asparagine (≈1%).

The predicted post-translational modifications for C15orf39 include phosphorylation, acetylation, sumoylation, and o-glycosylation.

An amino acid of importance is K17, which has an acetyl and sumo-group covalently attached.

[14][15] All predicted post-translational modifications were conserved in distant and strict orthologs.. .

Alpha helices predicted in the C15orf39 protein are colored red, and random coils are represented as tan.

[23] The ortholog space for C15orf39 includes relatives as distant as the cartilaginous fish like Rhincodon typus (whale shark), and as strict as closely related mammals like the Gorilla, which has 99% sequence identity to the human protein.

[24][25] The phylogenetic tree below, shows the evolutionary relationship of the C15orf39 protein sequence in its orthologs.

C15orf39's sequence has diverged at a quicker rate than the quickly evolving fibrinogen protein in humans.

Location of C15orf39 on chromosome 15. [ 3 ]
Expression of C15orf39 in human tissues. [ 6 ]
In-situ hybridization of C15orf39 in fetal and adult reticulocytes. [ 7 ]
Domains of C15orf39. P = Phosphorylation, A = Acetylation, SUMO = Sumoylation, O = O-glycosylation.
Conceptual translation of C15orf39 C-terminal showing predicted PTM and secondary structure.
Predicted tertiary structure for C-terminal end of C15orf39. [ 17 ]
Phylogenetic tree for select C15orf39 orthologs. [ 26 ]
Rate of sequence divergence for C15orf39, Fibrinogen, and Cytochrome C in orthologs. [ 27 ]